Polar Fractions
Polar Fractions: A Breakthrough in Active Pharmaceutical Ingredients
Revolutionizing Cannabis Science
One of the most groundbreaking discoveries in cannabis research is the revelation that polar fractions of specific cultivars exhibit far greater efficacy than their non-polar counterparts. This scientific breakthrough challenges the traditional focus on cannabinoids and terpenes, opening a new chapter in cannabis-based pharmaceuticals.
What Are Polar Fractions?
Polar fractions are composed of flavonoids, sugars, and other plant substances, while the levels of cannabinoids and terpenes are reduced to a minimum. Unlike traditional cannabis extracts, these polar fractions harness the power of the plant’s broader chemical composition, delivering targeted therapeutic benefits without the psychoactive effects associated with cannabinoids.
Groundbreaking Scientific Findings
A pivotal part of our research, published in the Journal of Cannabis Research (Read the Study), demonstrated that the effects of cannabis-based formulations were independent of the cannabinoid profile. This discovery sent shockwaves through the cannabis industry, which has traditionally focused on the importance of cannabinoids and terpenes.
The Entourage Effect Redefined
Traditionally, the entourage effect was believed to be dictated by the ratio of cannabinoids and terpenes. However, our findings revealed that the therapeutic potential is cultivar-specific rather than dependent on specific cannabinoid ratios. Once cannabinoids were removed, the toxic effects disappeared, while the effectiveness of the formulation significantly increased. This discovery represents a paradigm shift in how we understand and utilize cannabis in medical applications.
Pharmaceutical & Industrial Applications
The water-soluble nature of polar fractions makes them ideal for a wide range of pharmaceutical formulations and health products. These fractions can serve as:
A base for pharmaceutical products targeting mental wellbeing, appetite management, pain relief, fertility, performance management and vitality support.
An addition to various wellness products without regulatory restrictions.
Regulatory Advantage & Market Potential
A key benefit of polar fractions is that they do not fall under the Opium Act, as the cannabinoids are minimized to a legal threshold. This ensures greater flexibility for global distribution and broad commercial applications without legal restrictions.
Learn More & Collaborate With Us
For more information on the availability of different polar fractions or further scientific insights, please contact us. Join us in pioneering the next generation of cannabis-based pharmaceuticals with the power of polar fractions.


The key to unlocking the greatest health benefits lies in matching the right cultivar to specific conditions or target groups.
Santa Maria Pharmaceuticals B.V.
Warmenhuizen, The Netherlands info@santamariapharmaceuticals.com
KVK: 95159215
VAT: NL867024124

